Backing up my iOS devices with iMazing app means I can direct the backup location AWAY from the iMac’s internal drive. It also means that unlike with previous versions of iMazing, iTunes cannot be used to restore such backups: that has to be done with iMazing itself.

Fine by me. I have saved 39 GB of space in doing that. The backups were of the 128 GB iPad; 128 GB iPod Touch & the 64 GB iPhone.